After an impressive rookie season in 1983 (1808 rushing yards), Eric Dickerson of the Los Angeles Rams broke out in his sophomore season for 2105 rushing yards on 379 carries. His 2105 single season rushing yards total, still stands 25 years later. Jamal Lewis came within 50 yards back in 2003. Only 5 players in the history of the NFL have rushed for over 2000 yards in a season; Eric Dickerson, Jamal Lewis, Barry Sanders, Terrell Davis, and OJ Simpson.

NFL All-Time Leaders	NFL Single Season Leaders
Total Passing Yards Leaders	Passing Yards Leaders
Touchdown Passes Leaders	Touchdown Passes Leaders
Rushing Yards Leaders	Rushing Yards Leaders
Receiving Yards Leaders	Rushing Touchdowns Leaders
Touchdowns (RB and WR) Leaders	Receiving Yards Leaders
	Receiving Touchdowns Leaders

Single Season NFL Rushing Yards Leaders - 1600+ rushing yards
Rk	Player	Team	Yards	Year
1	Eric Dickerson	Los Angeles Rams	2,105	1984
2	Jamal Lewis	Baltimore Ravens	2,066	2003
3	Barry Sanders	Detroit Lions	2,053	1997
4	Terrell Davis	Denver Broncos	2,008	1998
5	O.J. Simpson	Buffalo Bills	2,003	1973
6	Earl Campbell	Houston Oilers	1,934	1980
T7	Ahman Green	Green Bay Packers	1,883	2003
T7	Barry Sanders	Detroit Lions	1,883	1994
9	Shaun Alexander	Seattle Seahawks	1,880	2005
10	Jim Brown	Cleveland Browns	1,863	1963
11	Tiki Barber	New York Giants	1,860	2005
12	Ricky Williams	Miami Dolphins	1,853	2002
13	Walter Payton	Chicago Bears	1,852	1977
14	Jamal Anderson	Atlanta Falcons	1,846	1998
15	Eric Dickerson	Los Angeles Rams	1,821	1986
16	O.J. Simpson	Buffalo Bills	1,817	1975
17	LaDainian Tomlinson	San Diego Chargers	1,815	2006
18	Eric Dickerson	Los Angeles Rams	1,808	1983
19	Larry Johnson	Kansas City Chiefs	1,789	2006
20	Emmitt Smith	Dallas Cowboys	1,773	1995
21	Adrian Peterson	Minnesota Vikings	1,760	2008
22	Marcus Allen	Los Angeles Raiders	1,759	1985
T23	Larry Johnson	Kansas City Chiefs	1,750	2005
T23	Terrell Davis	Denver Broncos	1,750	1997
25	Gerald Riggs	Atlanta Falcons	1,719	1985
26	Emmitt Smith	Dallas Cowboys	1,713	1992
27	Edgerrin James	Indianapolis Colts	1,709	2000
28	Michael Turner	Atlanta Falcons	1,699	2008
T29	Curtis Martin	New York Jets	1,697	2004
T29	Earl Campbell	Houston Oilers	1,697	1979
31	Shaun Alexander	Seattle Seahawks	1,696	2004
32	Frank Gore	San Francisco 49ers	1,695	2006
33	Barry Foster	Pittsburgh Steelers	1,690	1992
34	Walter Payton	Chicago Bears	1,684	1984
35	LaDainian Tomlinson	San Diego Chargers	1,683	2002
36	George Rogers	New Orleans Saints	1,674	1981
37	Jerome Bettis	Pittsburgh Steelers	1,665	1997
38	Tiki Barber	New York Giants	1,662	2006
39	Eric Dickerson	Indianapolis Colts	1,659	1988
40	Tony Dorsett	Dallas Cowboys	1,646	1981
41	LaDainian Tomlinson	San Diego Chargers	1,645	2003
42	Deuce McAllister	New Orleans Saints	1,641	2003
43	Corey Dillon	New England Patriots	1,635	2004
44	Priest Holmes	Kansas City Chiefs	1,615	2002
45	Walter Payton	Chicago Bears	1,610	1979
46	Ottis Anderson	St. Louis Cardinals	1,605	1979

** Updated Jan. 8th, 2009

Sources:
pro-football-reference.com
databasefootball.com
wikipedia.org
espn.com